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An early microscope was made in 1590 inMiddleburg, The Netherlands Three eyeglass makers are variously given credit: Hans Lippershey (who developed an early telescope); Zach arias Jansen, with the help of his father, Hans Janssen. Giovanni Faber coined the name for Galileo Galilee's compound microscope in 1625 (Galileo had called it the "occhiolino" or "little eye".)

The first detailed account of the interior construction of living tissue based on the use of a microscope did not appear until 1644, in Giambattista Odierna's L'ochio della mosca, or The Fly's Eye.

It was not until the 1660s and 1670s that the microscope was used seriously in Italy, Holland and England. Marcelo Malpighi in Italy began the analysis of biological structures beginning with the lungs. Robert Hooke's Micrographia had a huge impact, largely because of its impressive illustrations. The greatest contribution came from Antoni van Leeuwenhoek who discovered red blood cells and spermatozoa. On 9 October 1676, Leeuwenhoek reported the discovery of micro-organisms.

The most common type of microscope---and the first invented---is the optical microscope. This is an optical instrument containing one or more lenses producing an enlarged image of an object placed in the focal plane of the lenses

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