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The largest is the 1,296,000-acre Marjory Stoneman Douglas Wilderness in the Everglades National Park, Florida.

The Boundary Waters Canoe Area Wilderness in Minnesota is about 1.1 million acres (but is not quite east of the Mississippi R.)

The Okefenokee Wilderness, is Georgia, is 354,000 acres.

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Q: What is the largest wilderness are east of the Mississippi river?
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