Interstate 40
The main highway that runs along the California coast is California State Route 1, and the highway that runs along the East coast is U.S. Route 1.
A route highway map must (obviously) show the roads in an area, particularly the main through routes.
State Route 111 (SR 111) is a state highway in the U.S. state of California. It is the main north/south state highway and retail corridor through the Coachella Valley, a part of the Colorado Desert in the southeastern corner of the state. The Colorado Desert is a part of the Sonoran Desert.
I-235
The main highway in the Northern Territory is the Stuart Highway. Named after Scottish explorer John McDouall Stuart, who was the first to cross Australia south to north and back, the Stuart Highway roughly follows his track through central Australia.
The most famous street in London is probably Oxford Street but there are no main roads which go 'through' London, ie enter London from one side and emerge at the other.
Interstate 5 (I-5) runs north and south through the center of California, connecting major cities like Los Angeles, Bakersfield, Fresno, and Sacramento. It is one of the main transportation routes in the state, catering to both local and interstate traffic.
flat leaves and needles
The Lincoln Highway is often referred to as the "Main Street Across America." It was the first transcontinental highway in the United States, established in 1913, and served as a vital route for travelers and commerce. The highway symbolizes the early efforts to connect the nation through improved road infrastructure.
Highway robbery means to rob someone on a main thoroughfare;
A Roman highway or main road is called a "via".
Main road