The margin of safety is the dose of a drug that is lethal for 1% of tested animals divided by the dose that produces the maximum effect for 99% of tested animals. The larger this ratio is, the better you toxicology data will (and thus, the safer the drug will be)
potassium, excesses or deficits effect the hearts rhythm
LD50 (short for lethal dose 50) is the dose of a substance at which it kills 50% of test subjects.
true,however LD50 just provide coarse idea and specific adverse effect also need be considered.
238 mg/kg (in mice)
In toxicology, the median lethal dose, of a toxin is the dose required to kill half the members of a tested population after a specified test duration. LD50 figures are frequently used as a general indicator of a substance's acute toxicity.
3.333
Margin of safety ratio = margin of safety/sales revenue
Contribution of margin safety x margin of safety
The ED50 defined as the dose required to produce a defined therapeutic response in 50% of the population.
First you need to find the break even sales. Break even sales = fixed expenses/ CM ratio Break even sales = 3600/.24 = 15,000 Then find the margin of safety dollars. margin of safety dollars = budgeted sales - break even sales margin of satefy dollars = 200,000 - 15,000 = 185,000 Then you can find the margin of safety percent Margin of safety percent = margin of safety dollars/ budgeted sales dollars margin of safey percent = 185,000/200,000 = 92.5%
total sales - breakeven= marginal of safety
Margin of safety is the difference between the intrinsic value of a stock and its market price. To have a margin of safety, one must manage one's financial needs thriftily.
Margin of safety is the difference between the intrinsic value of a stock and its market price. To have a margin of safety, one must manage one's financial needs thriftily.
Time and Space
ld50 for lamotrigine
yes it can be negative.
Suspense - 1949 Margin for Safety 3-27 was released on: USA: 27 February 1951