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What does low therapeutic index mean?
Drugs with a low therapeutic index have a narrow margin of safety.
The dose of a drug which kills 50 animals was 60mgkg the dose of a drug which cured 50 animals was20mgkg calculate the therapeutic index of the drug?
The therapeutic index of a drug is determined by dividing the lethal dose (LD50) by the effective dose (ED50). In this case: Therapeutic index = LD50/ED50 = 60mg/kg / 20mg/kg = 3. This means that the drug has a therapeutic index of 3, indicating a relatively safe drug with a wide margin of safety.
What is the Therapeutic Index of Tobacco?
100
What is the therapeutic index of drugs?
The therapeutic index of drugs is the ratio between the amount of drug needed to kill 50% of the cells of the experimental animals and the dose needed for 50% of the cells to respond. The larger the therapeutic index, the safer the drug.
Is therapeutic index a useful measure of safety?
It is for certain drugs such as Digoxin as they have such a narrow therapeutic index. For drugs with a wide range of therapeutic index, the best measure of safety is the maximum daily dose, its effect on the patient and what other drugs it interacts with. Ask your pharmacist for specific safety questions on your specific drugs.
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