Drugs with a low therapeutic index have a narrow margin of safety.
The therapeutic index of a drug is determined by dividing the lethal dose (LD50) by the effective dose (ED50). In this case: Therapeutic index = LD50/ED50 = 60mg/kg / 20mg/kg = 3. This means that the drug has a therapeutic index of 3, indicating a relatively safe drug with a wide margin of safety.
100
The therapeutic index of drugs is the ratio between the amount of drug needed to kill 50% of the cells of the experimental animals and the dose needed for 50% of the cells to respond. The larger the therapeutic index, the safer the drug.
It is for certain drugs such as Digoxin as they have such a narrow therapeutic index. For drugs with a wide range of therapeutic index, the best measure of safety is the maximum daily dose, its effect on the patient and what other drugs it interacts with. Ask your pharmacist for specific safety questions on your specific drugs.
Yes these are the antibiotics which have the highest therapeutic index.. That too penicillin is exceptionally high... The only side effect which is considered significant from these two groups of antibiotics is Hypersensitivity reaction or allergis reaction which can be lethal also in some of them.. The reason is, both of these belong to a group of beta lactum antibiotics and they both have a protein structure and they are easily metabolised in the body.. If they ast on bacteria than they are antibiotics otherwise they are mere protein food, just like giving parentral nutrition... Hence they have a huge therapeutic index..
Digitalis has a very narrow therapeutic index, therefore, the dose must be carefully be monitored for each patient.
No. Foods with high refined sugar amounts have a high glycemic index.
in a book there is a section that tells you where things are.
high penetration index shows low temperature susceptibility, low penetration index shows high temperature suspectibility.
A high h-index in academic research is typically considered to be around 20 or higher.
No