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Any hardening of the brain is called encephalosclerosis.

If the hardening occurs in the cerebral hemispheres (as opposed to the rhombencephalon), it is called cerebrosclerosis. This is a morbid condition.

The hardening of arteries within the brain is a form of arteriosclerosis, which in most cases is atherosclerosis. The buildup of hardened scar tissue within the brain can also be caused by the demyelinating autoimmune disease multiple sclerosis.

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