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It means the middle of something, the part that is furthest from any part of the outside of something.
Centeral Africa
well... um the black widows body coverings are black with a red lightning bolt in the middle of it.
A Moat
Nervous about middle-east tensions, I suppose.
Sponges have no nervous systems, their middle jelly-like layers have large and varied populations of cells, and some types of cell in their outer layers may move into the middle layer and change their functions
5 time
It is made up of two parts, assessing the status of, and the protective mechanisms of the middle ear
Hey if you are nervous about what to wear the first day of middle school don't worry be yourself and you will find true friends
Recent insurrection in the Middle East has caused many nations to become nervous.
The spinal cord.
the middle layer, tunica media