Difficult to say. It would have to be one of the NBC weapons of mass destruction (Nuclear, Biological, Chemical).
Just my personal opinion, I would have to say a Biological weapon. Both Nuclear and Chemical weapons are inherently self limiting, their damage is massive but there is an end to it. Biological weapons can grow and reproduce and spread, eventually killing both original opponents and all noncombatants and neutrals.
The nuclear bomb
Massed artillery.
It is the most destructive weapon ever created.
The most destructive weapon on earth is the hydrogen bomb. These weapons are potentially thousands of times more powerful than ordinary atom bombs (which use nuclear fission rather than fusion) and could easily destroy a city in seconds.
A hydrogen bomb is, by far, the most destructive weapon that mankind has ever invented. It is the most powerful type of nuclear bomb.
not only for the explosive power, but also the fallout that follows, nuclear weapons are by far the most destructive force known to man.
biological
It was- and is- the most destructive weapon ever built. It is as dangerosu as any wepaon ever made, and is capable of completely destroying a large city.
The most destructive hurricane of 2005 was Hurricane Katrina. It was the most destructive hurricane ever recorded.
the super star holding 5 superlasers instead of 1. 4 outer lasers and 1 central laser.
Catrina is the most destructive hurricane.
yes, specifically nuclear fission.Well, yes. It was the weapon that ended World War 2 completely. We were just crazy enough to use the second most destructive weapon in ALL of human history.