Probably, almost certainly, the .600 Nitro Express is the overall most power handgun bullet.
Let me alter this answer by saying the .600 Nitro Express is a rifle round that one company made a pistol for. The most powerful handgun cartridge is the 500 S&W Magnum.
In most circumstances, no. The bullet is too large to chamber in the handgun.
No
Unknown
Demons are immortal - its just part of the definition.
ANY firearm that discharges a bullet is capable of causing a lethal injury. 500 smith and Wesson. Is a very lethal handgun.
A VERY good handgun- for most puposes. Durable, reliable, accurate, and powerful.
The magnum .55 is the most powerful, but some Desert Eagle has the highest calibre bullet.
Pistol.
No, you cannot.
No, it cannot.
Not even close. There are several more powerful handgun cartridges, not counting the single shot pistols that use rifle cartridges. While Dirty Harry may have proclaimed it to be "The most powerful handgun in the world"- it is not.
Arguably the IMI Desert Eagle in .50 AE.wrong to this day the most powerful handgun in production is the Austrian Pfeifer Zeliska it fires a .600 nitro express round ,this is a bullet favoured by big game hunters to down large prey such as elephants and rhino.Wrong again. The question is "What is the most powerful semi automatic pistol". The Pfeifer Zeliska is a single shotrevolver. There are some Wildey's out there that are fairly large (475 Wildey Mag) that are on par ballistic-ally with the Desert Eagle .50AE but the DE is the largest production semi auto.