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The hormone Calcitonin has the effect of reducing blood calcium levels. The hormone comes from the thyroid gland and works in basically three ways. 1. It works to slow absorption of calcium by the intestine. 2. It also inhibits the osteoclast (cells in bone that break down old bone tissue) that raise blood calcium levels. 3. It causes osteoblast (cells in bone that lay down new bone matrix) to form new bone. This explanation is at it's simplest form of course.
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PTH is secreted by the parathyroid glands (which are attached to your thyroid) and acts on bone (via increased bone resorption) , the kidneys (via increased reabsorption of calcium) and the intestine (increased calcium absorption by increased levels of activated vitamin D) to increase blood calcium levels.
True, blood calcium is very tightly regulated there are two types of bone cells that will either take up excess calcium if blood levels get too high or break down bone to release calcium if blood levels get to low. Both of these bone cells are controlled by the endocrine system in the body.
Osteoclasts which break down existing bone matrix and osteoblasts which lay down new bone matrix in areas that are under the greatest stress such as gravity or where muscles pull on bones.
Bones are dynamic in the sense that they are constantly being broken down and built back up. When blood calcium levels are low, cells called osteoclasts break down bone matrix and release the calcium into the blood. When blood calcium levels are high, cells called osteoblasts take calcium out of the blood and use it the built bone matrix.
Parathyroid gland secrete parathyroid hormone called PTH. PTH regulates calcium level in the body by transferring calcium from the bone and when body has excess calcium, PTH helps them to deposit into the bone.
Because bone stores of calcium can be used to maintain adequate blood calcium levels, short-term dietary deficiency of calcium generally does not result in significantly low blood calcium levels. But, over the long term, dietary deficiency eventually depletes bone stores, rendering the bones weak and prone to fracture. A low blood calcium level is more often the result of a disturbance in the body's calcium regulating mechanisms, such as insufficient PTH or vitamin D, rather than dietary deficiency. When calcium levels fall too low, nerve and muscle impairments can result. Skeletal muscles can spasm and the heart can beat abnormally-it can even cease functioning.
The sole function of the parathyroid glands is to maintain the body's calcium level within a very narrow range, so that the nervous and muscular systems can function properly. When blood calcium levels drop below a certain point, calcium-sensing receptors in the parathyroid gland are activated to release hormone into the blood. Parathyroid Hormone (PTH, also known as parathormone) is a small protein that takes part in the control of calcium and phosphate homeostasis, as well as bone physiology. PTH has effects antagonistic to those of calcitonin. PTH increases blood calcium levels by stimulating osteoclasts to break down bone and release calcium. PTH also increases gastrointestinal calcium absorption by activating vitamin D, and promotes calcium uptake by the kidneys.