Actin changes shape.
Actin Changes ShapeApexMyosin binds to ActinAPEX
Calcium binds to troponin, which moves the tropomyosin out of the way so that myosin can bind to actin; this ultimately causes a power-stroke.
Actin Changes ShapeApexMyosin binds to ActinAPEX
Yes, calcium is necessary for the release of neurotransmitters that cause a muscle to initiate a contraction. Calcium is also needed to bind to the troponin-tropomyosin complex causing it to change position so the myosin head can attach to the actin molecule which results in contraction.
Calcium binds to the messenger protein Calmodulin. The calcium-calmodulin complex then activates myosin light chain kinase (MLCK), which phosphorylates myosin to allow it to bind to actin - producing contraction.
tropomyosin moves out of the groove between the actin molecules.
Actin Changes ShapeApexMyosin binds to ActinAPEX
Actin Changes ShapeApexMyosin binds to ActinAPEX
Muscle contraction in initiated by an action potential sent from the brain or spinal cord to the axon terminal of a motor neuron. Calcium then goes into the axon terminal which causes the release of the neurotransmitter acetylcholine which binds to receptors on the plasmalemma. Calcium then diffuses into the sarcoplasm and binds to troponin. The troponin is then shifted to expose binding sites on the actin filament allowing for the linkage of actin and myosin. The the actin filaments are then pulled inward during shortening the sarcomere and resulting in muscular contraction :) I learnt this stuff in year 9
During skeletal muscle contraction calcium ions expose myosin binding sites on to the actin. When a nerve sends a signal to a muscle to do some "action" the release of acetylcholine at the neuromuscular junction triggers calcium to be released into the cytoplasm. At rest, the cell has a low concentration of calcium. When the calcium concentration rises, calcium diffuses over to the muscle protein fibers and causes a conformational change. Calcium binds to the troponin and causes it to rotate slightly which forms a crossbridge that drags along the actin fiber and shortens it thus creating muscle fiber contraction.
triggers neurotransmitter secretion, removes contraction inhibitor, and binds with troponin.
Actin and myosin