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It depends on the intrinsic properties of the drug and the route of administration. Oral drugs are often absorbed from the GI tract into the hepatic portal vein, undergo first pass, and then reach the systemic circulation.

They can be biotransformed (metabolized) in the liver, kidneys or even lungs. Most drugs are excreted by the kidneys into the urine, but some are excreted into bile by the liver.

Blood flow to particular organs, and the relative lipophilicity of the drug affect how it will behave in the body. It's metabolism is also key in figuring out how it will be excreted.

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June Douglas

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3y ago

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