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Rett Syndrome is most severe of the autism spectrum disorders; affecting language, mobility, hand-use, and growth of the head and spine. Kids with Rett's usually have normal developmental trajectory in throughout the first year of life, and then drastically regress in neurodevelopment, and slowly continue to deteriorate. The ailment almost always affects girls. 50% of kids with Rett's don't walk at all, and in some really profound cases, a girl can't swallow her own saliva, and needs a feeding tube. There's an argument about whether or not this disease should be considered a subtype of autism. Unlike Rett's, classical autism isn't progressive, nor does it lead to premature death. Average life expectancies of Rett's range from 20-40 years. Autism affects about 1 in 150 children of each gender, while Rett's affects about 1 in 10,000-22,000 female births.

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