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Is ALS hereditary?
Amyotrophic lateral sclerosis (ALS) can be hereditary in some cases, known as familial ALS, which accounts for about 5-10% of all cases. The majority of ALS cases are sporadic, meaning they occur without a clear genetic link. Certain genetic mutations, such as those in the C9orf72, SOD1, and TARDBP genes, have been associated with familial ALS. However, even in sporadic cases, genetic factors may still play a role alongside environmental influences.
How can you get ALS?
The cause of sporadic amyotrophic lateral sclerosis ( about 90% of cases) is largely unknown but probably involves a combination of genetic and environmental factors. About 10 percent of people with amyotrophic lateral sclerosis have a familial form of the condition, which is caused by an inherited genetic mutation.
In als what chromosome is affected?
In ALS, also known as amyotrophic lateral sclerosis, the chromosome primarily affected is chromosome 9. A gene called C9orf72 located on this chromosome is linked to a significant percentage of familial ALS cases. Other genetic mutations on different chromosomes can also contribute to ALS development.
What are the genes and chromosomes affected by Lou Gehrig's Disease?
Lou Gehrig's disease, or amyotrophic lateral sclerosis (ALS), is primarily caused by mutations in the C9orf72, SOD1, FUS, and TARDBP genes. These mutations can lead to the degeneration of motor neurons in the brain and spinal cord. ALS is not specifically linked to a particular chromosome.
How many cases of als in brittian?
As of the latest data, there are approximately 5,000 people living with amyotrophic lateral sclerosis (ALS) in the UK. The incidence of ALS is about 1-2 cases per 100,000 people annually. While the exact numbers can fluctuate, ALS remains a relatively rare neurological condition compared to other diseases. For the most accurate and current statistics, it's advisable to consult health organizations or research studies focused on ALS in Britain.
What causes permanent paralysis?
Permanent paralysis can result from various causes, including severe spinal cord injuries, neurological diseases (such as amyotrophic lateral sclerosis or multiple sclerosis), stroke, or conditions that damage the nerves, like traumatic brain injuries. These injuries disrupt the communication between the brain and the muscles, leading to a loss of voluntary movement and sensation. In some cases, underlying conditions like infections or tumors can also contribute to paralysis. The degree and permanence of paralysis depend on the severity and location of the injury or disease.
What are the demographics of ALS?
About 20,000 people in the United States have ALS at any given time with 5,000 new cases diagnosed every year. Persons of all races and ethic groups are afflicted by the disease, although men are more likely to have it than women.
Can a MRI detect ALS?
An MRI cannot directly diagnose amyotrophic lateral sclerosis (ALS), as it does not show the specific nerve cell damage characteristic of the disease. However, it can help rule out other conditions that may mimic ALS symptoms by providing detailed images of the brain and spinal cord. In some cases, an MRI may show changes associated with upper motor neuron degeneration, but these findings are not definitive for ALS. Diagnosis typically relies on clinical evaluation and electromyography (EMG) testing.
What is the prognosis for Empyema?
The prognosis for recovery is generally good, except in those cases with complications, such as a brain abscess or blood poisoning, or cases caused by certain types of streptococci
Can there be a connection between ataxia and ALS?
Yes, there can be a connection between ataxia and amyotrophic lateral sclerosis (ALS), as both conditions affect the nervous system. Ataxia, characterized by lack of voluntary coordination of muscle movements, can sometimes occur in ALS patients due to the degeneration of motor neurons that control muscle function. Additionally, some forms of ataxia may share genetic or pathophysiological links with ALS, leading to overlapping symptoms in certain cases. However, they are distinct conditions with different underlying mechanisms.
When does diagnosis of ALS usually occur?
Diagnosis of Amyotrophic Lateral Sclerosis (ALS) typically occurs between the ages of 40 and 70, with most cases diagnosed in individuals around 55. Symptoms often begin subtly, such as muscle weakness or twitching, leading to a gradual progression that can be mistaken for other conditions. Due to the complexity of the disease and overlap with other neurological disorders, diagnosis may take several months to years, often requiring a combination of clinical evaluation and diagnostic tests. Early recognition is crucial for management and support options.
What is the prognosis for SVCS?
In cases of SVCS caused by lung cancers, the prognosis is generally rather poor since SVCS does not generally occur until the later stages of these diseases.
