The life expectancy of patients with type C is variable. Some patients die in childhood while others, who appear to be less drastically affected, live into adulthood.
With Types C and D NPD, there is significant nervous system damage leading to severe muscle spasms, seizures, and eventually, to coma and death.
Patients with NPD-A commonly die during infancy. NPD-B patients may live for a few decades, but many require supplemental oxygen because of lung impairment.
The prognosis for children with Types C and D Niemann-Pick disease (NPD) is typically poor. These types of NPD are severe and progressive, leading to significant neurological decline and ultimately early death. Treatment options are limited, and supportive care is often provided to manage symptoms and maximize quality of life.
Type B patients generally live to adulthood but suffer from significant liver and lung problems.
The prognosis for TGA patients is excellent
The prognosis for TGA patients is excellent
Patients with Type A NPD usually die within the first year and a half of life.
There is no recovery from NPD. The American Psychiatric Association recognizes it as permanent and incurable.
Prognosis is generally good for patients with pernicious anemia
The vast majority of children with NPD-C die before age 20, and many before the age of 10.
The prognosis for reversing vitamin toxicity is excellent for most patients
NPD-C is diagnosed by taking a small skin biopsy , growing the cells (fibroblasts) in the laboratory, and studying their ability to transport and store cholesterol.