Drive to Jacksonville FL and take I-95 toward Savannah GA and then US-278 East
492 miles
Hilton Head is in South Carolina, about 40 miles from Savannah.
Charleston, South Carolina is 98 miles away from Hilton Head Island, South Carolina. It would about 2 hours to drive by car.
It is 380.13 miles accordig to MapQuest.
According to google maps, the trip to from Hilton Head Island to Charleston, SC is a 2 and a half hour drive.
It is 313 miles according to Google Maps.
The halfway point between Bartow, Florida and Greenville, South Carolina falls in Townsend, Georgia.
Using Google Maps one is able to calculate the distance as well as the driving travel time. The distance between Delray Beach, Florida and Hilton Head, South Carolina is 473 miles. The travel time is 7 hours and 53 minutes.
About 600 miles
400m1
The closest town to midway between Sanibel Island, Florida and Hilton Head Island, South Carolina is Citra, Florida. The closest large town is Gainesville, Florida but it's a little way off the shortest route.
Between Georgia and what??? Between Georgia and Florida is well, nothing - they touch each other. Between Georgia and North Carolina is South Carolina. Between Georgia and Mississippi is Alabama.