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Bone pain, particularly in the backbone, hips, and skull, is often the first symptom of multiple myeloma. As malignant plasma cells increase in the bone marrow, replacing normal marrow, they exert pressure on the bone.
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What are the signs and symptoms of Multiple Myeloma?
Some of the common signs and symptoms of Multiple Myeloma are 1) bone pain, 2) susceptibility to infections, 3) anemia, 4) kidney disease, and 5) neurological symptoms.
What are the most common multiple myeloma symptoms?
The common symptoms of multiple myeloma are bone pain, broken bones, anemia, and leukopenia. Should these signs ever appear, it is wise to consult with the doctor. However, keep watch for these other major symptoms as well: compressed nerves, hypercalcemia, and kidney damage.
Is there a connection with spina bifada and lately excruciating tailbone pain.?
I don't know about the relationship between spina bifada, but my father had what you describe as excruciating tailbone pain and his diagnosos was multiple myeloma. I'm told multiple myeloma is sometimes difficult to diagnose but that the tailbone pain is common.The good news is that I know a man in my town who has had the disease (mm) for over 5 years and he is active and appears to be in great health.
Multiple myeloma?
DefinitionMultiple myeloma is cancer of the plasma cells in bone marrow.Alternative NamesPlasma cell dyscrasia; Plasma cell myeloma; Malignant plasmacytoma; Plasmacytoma of bone; Myeloma - multipleCauses, incidence, and risk factorsPlasma cells help the body's immune system fight disease by producing proteins called antibodies. In multiple myeloma, plasma cells grow out of control in the bone marrow and form tumors in the areas of solid bone.The growth of these bone tumors makes it harder for the bone marrow to make red blood cells, white blood cells, and platelets. This causes anemia, which makes a person more likely to get infections and have abnormal bleeding.As the cancer cells grow in the bone marrow, they can cause pain and destruction of the bones. If the bones in the spine are affected, it can put pressure on the nerves, resulting in numbness or paralysis.Multiple myeloma mainly affects older adults. A history of radiation therapy raises your risk for this type of cancer.SymptomsBleeding problemsBone or back pain, most often in the ribs or backFevers without any other causeIncreased susceptibility to infectionSymptoms of anemia (such as tiredness, shortness of breath, and fatigue)Unexplained fracturesWeakness of the arms or legsSigns and testsBlood tests can help diagnose this disease. They may include:Blood chemistrymay show increased levels of calcium, total protein, and abnormal kidney functionComplete blood count (CBC) reveals low numbers of red and white blood cells and plateletsSerum beta 2 microglobulin levelSerum immunofixation electrophoresisUrine immunofixation electrophoresisSerum protein electrophoresis (SPEP)Urine protein electrophoresis (UPEP) or Bence-Jones protein analysisQuantitative immunoglobulins (nephelometry)Serum free light chain measurementsBone x-rays may show fractures or hollowed out areas of bone. If your doctor suspects this type of cancer, a bone marrow biopsy will be performed.Bone density testing may show bone loss.TreatmentThe goal of treatment is to relieve symptoms, avoid complications, and prolong life.People who have mild disease or where the diagnosis is not certain are usually carefully watched without treatment. Some people have a slow-developing form of multiple myeloma that takes years to cause symptoms.Medications for the treatment of multiple myeloma include:Dexamethasone, melphalan, thalidomide, lenalidomide (Revlimid), and bortezomib (Velcade) can be used alone or together.Drugs called bisphosphonates (pamidronate) are used to reduce bone pain and prevent fractures.Radiation therapy may be performed to relieve bone pain or treat a bone tumor.Two types of bone marrow transplantation may be tried:Autologous bone marrow or stem cell transplantation makes use of one's own stem cells. In younger patients, it has been shown to increase survival.Allogeneic transplant makes use of someone else's stem cells. This treatment carries serious risks.People with multiple myeloma should drink plenty of fluids to prevent dehydrationand help maintain proper kidney function. They should also be cautious when having x-ray tests that use contrast dye.Support GroupsThe stress of illness may be eased by joining a support group whose members share common experiences and problems. See: Cancer - support groupExpectations (prognosis)Survival of people with multiple myeloma depends on the patient's age and the stage of disease. Some cases are very aggressive, while others take years to get worse.Chemotherapy and transplants rarely lead to a permanent cure.ComplicationsKidney failureis a frequent complication. Other complications may include:Bone fracturesHigh levels of calcium in the blood, which can be very dangerousIncreased chances for infection (especially pneumonia)Paralysis from tumor or spinal cord compressionCalling your health care providerCall your doctor if you have multiple myeloma and infection develops, or numbness, loss of movement, or loss of sensation develops.ReferencesNational Comprehensive Cancer Network Clinical Practice Guidelines in Oncology: Multiple Myeloma. National Comprehensive Cancer Network; 2010. Version 1.2010.Abeloff MD, Armitage JO, Niederhuber JE, Kastan MB, McKenna WG, eds. Abeloff's Clinical Oncology. 4th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2008:chap 110.
How is bone marrow cancer best treated?
Bone marrow cancer, also known as multiple myeloma, is a type of cancer that affects plasma cells in the bone marrow. Treatment for multiple myeloma is typically individualized based on the stage of the disease, the patient's overall health, and various other factors. Common treatment options for multiple myeloma may include the following: Chemotherapy: Chemotherapy drugs are often used to kill or slow the growth of cancer cells in the bone marrow. Targeted Therapies: Medications like proteasome inhibitors (e.g., bortezomib, carfilzomib) and immunomodulatory drugs (e.g., lenalidomide, thalidomide) target specific proteins or pathways in cancer cells to inhibit their growth. Immunotherapy: Immunotherapies, such as monoclonal antibodies (e.g., daratumumab, elotuzumab), enhance the body's immune response to target and destroy cancer cells. Stem Cell Transplantation: Autologous stem cell transplant (using the patient's own stem cells) or allogeneic stem cell transplant (using donor stem cells) may be considered to replace damaged bone marrow with healthy cells. This can be an option for some patients, particularly in cases of more aggressive disease. Radiation Therapy: Radiation therapy may be used to target specific areas where the cancer has formed tumors or is causing bone pain. Bisphosphonates: These drugs are used to strengthen bone and reduce the risk of fractures in patients with multiple myeloma, as the disease can weaken the bones. Supportive Care: Managing symptoms and complications is an essential part of treatment. This may include pain management, addressing anemia, and providing medications to manage side effects. Clinical Trials: Participation in clinical trials can provide access to cutting-edge treatments and therapies that are still in the experimental phase. Maintenance Therapy: Some patients may receive ongoing or maintenance therapy to help keep the disease in check and extend periods of remission. Treatment plans are tailored to the individual patient, and they may evolve over time based on the patient's response to therapy and the progression of the disease. It's essential for individuals diagnosed with bone marrow cancer to work closely with a team of healthcare professionals, including hematologists or oncologists, to determine the most appropriate treatment plan for their specific case. Additionally, multiple myeloma is a complex disease, and new treatments and therapies are continually being developed. Therefore, staying informed about the latest advances in multiple myeloma treatment and considering second opinions from specialists are important aspects of managing the condition.
Why does the funny bone tingle when you hit it?
Well your funny bone is in your elbow area and it has multiple nerve endings. The funny feeling could be pain, or a tickling feeling!
Does myelofibrosis cause bone pain?
It can cause bone pain, especially in the legs
Is an x ray necessary if you have bone pain?
An x-ray is a great tool for diagnosing bone pain. Other methods which can be used to investigate bone pain are CT Scans and MRIs which can render a 3D image of the area where the bone pain is occurring.
What are some causes of bone pain?
Bone pain can be caused by something as simple as a break, or something as bad as bone cancer. Get it checked out.
What is ostealgia?
Ostealgia. Is a pain a bone. Or weaking of bone.
Why you have pain after bone mallow test?
after bone mallow test some one herniation made it cause pain
CAN YOU STOP KNEE PAIN WHEN THERE IS BONE ON BONE WITH NO ARTILEGE OR MENESCUS?
This is called bone marrow edema. It can cause bleeding in the bone marrow, leading to severe pain. The injury is caused by an impact to the knee area.
