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What is the Process by which ACh gets across cleft?
Acetylcholine (ACh) is released from the presynaptic neuron into the synaptic cleft. It then binds to ACh receptors on the postsynaptic neuron, causing ion channels to open and allowing for the transmission of the nerve impulse. Any remaining ACh is broken down by the enzyme acetylcholinesterase, ensuring that the signal is quickly terminated.
How is acetylcholine (ACh) removed from the synaptic cleft?
Acetylcholine is degraded by acetylcholinesterase
Why doesn't acetylcholine remain on the post-synaptic process?
Acetylcholine (ACh) does not remain on the post-synaptic membrane because it is rapidly broken down by the enzyme acetylcholinesterase. This enzymatic degradation occurs in the synaptic cleft, preventing prolonged stimulation of the post-synaptic receptors. Additionally, the reuptake of choline into the pre-synaptic neuron helps recycle components for future neurotransmitter synthesis. This process ensures that synaptic transmission is brief and precisely regulated.
What destroys ACh?
Acetylcholinesterase (AChE) is an enzyme that breaks down acetylcholine (ACh) into choline and acetate, thus destroying ACh. This process helps in regulating the levels of ACh at the synaptic cleft and terminating its action.
How is acetylcholine (ACh) removed from the synaptic cleft?
Acetylcholine (ACh) is removed from the synaptic cleft through a process called enzymatic degradation. The enzyme acetylcholinesterase breaks down ACh into its components, acetate and choline, which are then taken back up into the presynaptic neuron for recycling or further processing.
How does the drug Neostigmine work to increase the bodys synaptic performance?
it blocks things [such as acetylchoinesterase] that break down ach
After nervous stimulation stops ACh in the synaptic cleft is prevented from continuing stimulation of contraction by what?
acetylcholinesterase destroying the ACh
After nervous stimulation stops what prevents ACh in the synaptic cleft from continuing to stimulate contraction?
Acetylcholinesterase destroying the ACH
Why physostigmine is the antidote for atropine?
Physostigmine inhibit AchE (the enzyme that hadrolyse Ach), so Ach accumulate at synaptic cleft and banish the effect of atropine
How is neostigmine chemically used to treat myasthenia gravis?
Neostigmine is a competitive irreversible inhibitor of Acetylcholinesterase (AChE), an enzyme responsible for breaking down acetylcholine (ACh). Myasthenia gravis is caused by the body producing too little ACh receptors. As stimulating the ACh receptors is needed for nervous transmission, the nerve signals cannot be transmitted causing muscle weakness and fatigue. Neostigmine is hence used to inhibit AChE so that less ACh gets broken down. This leads to more ACh binding to the ACh receptors causing muscular contraction.
What is the name of the cell that releases the neurotransmitters?
Exocytosis. As a result of the influx of Calcium ions, the synaptic vesicles transport the neurotransmitter Ach (Acetylcholine) to the presynaptic membrane, the vesicles fuse to the membrane, and the neurotransmiffer, Ach, diffuses. Once the neurotransmitters cross the synaptic cleft, they bind to the receptors on the post synaptic membrane. Hope it helps a bit.
What enzyme has to be present for acetylcholine to be broken down so that the muscle fiber can relax?
Acetylcholinesterase is the enzyme responsible for breaking down acetylcholine in the synaptic cleft, allowing the muscle fiber to relax. This enzyme catalyzes the hydrolysis of acetylcholine into acetate and choline, preventing continuous stimulation of the muscle.
