The only US $50 bill with an E series letter is 1950. There's more information at the question "What is the value of a 1950 E US 50 dollar bill?".
If your bill has any other date, you may be looking at the Federal Reserve District letter. The series letter, if any, on US bills is next to the date. In that case, please check the date and post a new question.
Bills printed in 1969 and later are only worth face value.
Face value to $25 if circulated; around $50 if crisp and uncirculated.
Please post a new question with one of the most important details - the bill's date.
You didn't provide a specific date but 1969 is the only series in the last 50 years to have a "B" letter. Please see the question "What is the value of a 1969 B US 20 dollar bill?" for more information.
$50
Probably slightly over face value
The value of a 1929G two dollar bill varies by circulation. A heavily circulated bill has very little additional value. An bill in good condition is worth about $10. A fully uncirculated bill is worth around $50.
Us $50 :-d
50 Canadian dollars.
It's still worth $50.
Yes... fifty dollars.
In circulated condition it has no added value. A nice, crisp uncirculated one is worth about $55 if you can find an interested buyer.