The disease called the plague. It didn't close all public places, though--churches remained open.
Bubonic Plague
Queen Elizabeth I arranged to have her cousin Queen Mary of Scotland killed in 1578, when Shakespeare was fourteen. This is the only queen who was killed at this time.
113 so far, but there are still hundreds reported missing.
Yes, the communist governments behind the 'Iron Curtain' killed & imprisoned thousands of people in their own countries, and killed & kidnaped hundreds outside of their countries (in-peace time). Also Josef Stalin in the USSR murdered millions during his reign of terror. Hundreds were also killed & wounded trying to escape the 'Iron Curtain' to the west.
Macduff did.
Answer this question… Hundreds of American soldiers were killed in bombings.
Highly unlikely
Shakespeare was alive later than when the plague killed Europe.
He was killed by forty Roman senators who called themselves Liberators.
Nobody. He simply died from old age.
Japan
There were hundreds that were killed in action. Some were in American units. The PR 65th Regiment lost many during the conflict.