One of the major rivers that runs through the Great Plains is the Canadian River.
Rio grande
Mississsippi river
Mississippi River or as my friend here believes the Missouri River, but i am right so go with the Mississippi.
Mississippi river to the east and the rocky mountains to the west
Arkansas river
The Mississippi River flows parallel to the Great Plains and the Appalachian Mountains in the United States. It starts in northern Minnesota and flows south to the Gulf of Mexico, approximately dividing the country into east and west.
Rocky Mountains --->Great Plains--->Mississippi River---> Appalachian Mountains
The Great Plains is the huge expanse of flatlands from the Rocky Mountains eastward to the Mississippi River.
Some major US physical features include the Rocky Mountains, the Great Plains, the Mississippi River, the Great Lakes, and the Appalachian Mountains.
the great plains
The Missouri River separates the Great Plains from the Central Plains.
The Great Plains