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What might happen if apoptosis did not occur in cells that have significant DNA damage?
Wiki User
∙ 9y ago
Most likely cancer would arise if apoptosis did not occur in cells that have significant DNA damage.
Wiki User
∙ 9y ago
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Why is apoptosis potentially threatening to the healthy neighbors of a dying cell?
Lysosomal enzymes exiting dying cell would damage surrounding cells
What is Apoptosis and what role does it play?
Apoptosis is when cells destroy themselves. This is done for two main reasons:To destroy cells which are a risk to the organism, such as cells with viruses.It is important in normal development, such as shedding the lining of the uterus (menstruation).
What type of cells undergo apoptosis?
Apoptosis is the process of controlled cell death. The cell undergoing apoptosis uses it own energy to efficiently dispose of cellular material with minimal damage to surrounding tissue. All cells can undergo apoptosis if they reach a stage whereby they recognise (through complex cellular feedback mechanisms) that they are unable to continue operating efficiently. This is not to be confused with Necrosis, which is an uncontrolled 'catastrophic' cell death pathway. Necrosis is usually a result of serious tissue damage and results in the death of multiple cells in an uncontrolled manner, leaving cellular debree throughout the tissue. This results in inflamation and further damage to the tissue. Sincerely, Your friendly neighbourhood biomedical scientist.
Why do Cancer cells in an organ make the organ less efficient?
Cancerous cells are ones that reproduce contantly and ignore apoptosis signals (death signals) to self-destruct, thereby preventing damage and more innefective cells. They do not function correctly, usually from irreperable DNA damage which would normally mean they would perform apoptosis to not cause further harm. Cancerous cells, however, ignore these "death" signals and continue to reproduce, even though they do not function. Enough of these cancerous cells together form a tumor, and tumors on organs can affect the surrounding tissue cells and cause a loss of functional efficiency.
How apoptosis can prevent abnormal cells from becoming tumors?
Apoptosis might be seen as part of the body's overseeing/managing/protecting mechanism. Apoptosis is associated with cell death; a programmed cell death, where "abnormal" cells, which either cannot function properly (aged, injured, etc), or are potential threat to the organism (infected, mutated), have to die. By activating apoptosis of those cells, the body stops their proliferation. If this mechanism gets impaired (for example tumour suppressor genes, like p53, cannot promote apoptosis), the uncontrolled proliferation of the abnormal cells could lead to malignancy.
What can cause a cell to die?
In simple terms cells perform apoptosis in which the program thereself to die through a series of key regulatory proteins. Examples include: when the cells maintain injury to parts or to specific parts of DNA or when the cells are infected with viruses. In other words cells can 'program' to die when mechanical damage is sustained or when external factors come into play. The outcome is to protect the organism as a whole.
Is apoptosis a feature of malignant cells?
No, that's the opposite, most malignant cells have lost their ability to undergo apoptosis.
Why is apoptosis potentially threatening to the healthy neighbors of a dying cell?
Lysosomal enzymes exiting dying cell would damage surrounding cells
Does cell damage change cell metabolism?
Yes...and....No...but mainly yes cell damage and death will cause changes in the cell metabolism, but this may or may not have a significant effect on the bodies metabolism as a whole. "Cell Damage" is a broad subject that depends on what type of cells, what tissue those cells make up, and where the source of damage originates. Different cells have different metabolic rates depending upon their activity. Cell damage occurs in many different ways, naturally occurring cell damage is the most common form. A series of chemical reactions happen in the body with metabolism. Mitochondria within the cell serve as the power base by converting the food we eat into Adenosine Triphosphate (ATP) "energy". Apoptosis plays a key role in metabolism, certain cells have different lifespans within the body and apoptosis helps maintain the homeostasis of the body by removing dead cells. This is where it gets tricky, since different cells have different lifespans and some high metabolism and some have low metabolism. The dead cells, upon completion of their lifespan, are removed by apoptosis. Normal apoptosis occurs with automatic digestion of the cells content. When the dispersion of the cells content is is near completion a signal from the cell attracts phagocytes that remove the dead cell without any adverse reaction. Too much apoptosis causes cell-loss disorders such as osteoporosis and some excessive cell-loss disorders can cause uncontrolled replication of mutated cells resulting in disorders primarily cancer. "Abnormally high metabolic rates associated with diseases such as cancer cause sudden weight loss." Many other factors such as "free radicals" affect the cells ability to function normally and thereby cause abnormal metabolism. Histological examination of suspect cells can reveal many disorders associated with abnormal metabolic rates.
How do human cells die?
by apoptosis and necrosis
Contrast apoptosis and cancer?
Cancer is the uncontrolled growth and division of cells. Apoptosis is a programmed cell death.
What is Apoptosis and what role does it play?
Apoptosis is when cells destroy themselves. This is done for two main reasons:To destroy cells which are a risk to the organism, such as cells with viruses.It is important in normal development, such as shedding the lining of the uterus (menstruation).
What 2 things happen when cells die?
In simple terms cells perform apoptosis in which the program thereself to die through a series of key regulatory proteins. Examples include: when the cells maintain injury to parts or to specific.
What type of cells undergo apoptosis?
Apoptosis is the process of controlled cell death. The cell undergoing apoptosis uses it own energy to efficiently dispose of cellular material with minimal damage to surrounding tissue. All cells can undergo apoptosis if they reach a stage whereby they recognise (through complex cellular feedback mechanisms) that they are unable to continue operating efficiently. This is not to be confused with Necrosis, which is an uncontrolled 'catastrophic' cell death pathway. Necrosis is usually a result of serious tissue damage and results in the death of multiple cells in an uncontrolled manner, leaving cellular debree throughout the tissue. This results in inflamation and further damage to the tissue. Sincerely, Your friendly neighbourhood biomedical scientist.
Radiation most likely destroys cancer cells by inducing a process called?
Radiation therapy primarily destroys cancer cells through a process called apoptosis, which is programmed cell death. When cancer cells are exposed to high-energy radiation, such as X-rays or gamma rays, it damages the DNA within the cells. This damage can lead to the activation of signaling pathways that trigger apoptosis, causing the cancer cells to die. Radiation therapy is designed to target and kill cancer cells while minimizing damage to healthy surrounding tissues. By inducing apoptosis in cancer cells, radiation therapy aims to shrink tumors and reduce the spread of cancer throughout the body.
Why do Cancer cells in an organ make the organ less efficient?
Cancerous cells are ones that reproduce contantly and ignore apoptosis signals (death signals) to self-destruct, thereby preventing damage and more innefective cells. They do not function correctly, usually from irreperable DNA damage which would normally mean they would perform apoptosis to not cause further harm. Cancerous cells, however, ignore these "death" signals and continue to reproduce, even though they do not function. Enough of these cancerous cells together form a tumor, and tumors on organs can affect the surrounding tissue cells and cause a loss of functional efficiency.
How apoptosis can prevent abnormal cells from becoming tumors?
Apoptosis might be seen as part of the body's overseeing/managing/protecting mechanism. Apoptosis is associated with cell death; a programmed cell death, where "abnormal" cells, which either cannot function properly (aged, injured, etc), or are potential threat to the organism (infected, mutated), have to die. By activating apoptosis of those cells, the body stops their proliferation. If this mechanism gets impaired (for example tumour suppressor genes, like p53, cannot promote apoptosis), the uncontrolled proliferation of the abnormal cells could lead to malignancy.
