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some problems or difficulties were location, starvation, drought, disease, Indians, and preparation.
Poor health
Many colonists died from disease
Poor Health
The colonists where looking for gold instead of farming and the colony was in the middle of a swamp.
they ran out of food
How did Jamestown colonists adapt to their environment?
the colonists came from England
many jamestown colonists became sick from malaria and from the drinking water
Many colonists died from disease
Poor health.
You basically said it in your question. The ground was swampy so the water was bad, there were mosquitoes, and disease.