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In mammals the muscles that participate in the breathing process are the diaphragm and the intercostal muscles. In respiratory insufficiency other muscles can help the respiration, the muscles of the shoulders, neck, thorax and abdomen.

The diaphragm (exclusive of mammals) and the intercostal muscles can contract or relax varying the volume of the thorax (the compartment where the lungs are located). The changing of the thorax volume forces inhalation or expiration. When the thorax volume is increased an internal pressure lower than the atmospheric pressure (external) is created and gases naturally enter the lungs. When the thorax volume is lowered the internal pressure rises above the external pressure and the air is expelled from the lungs.

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