To give you the simplest (and most obvious answer), the Great Plains is a region istself, and therefore that makes your question rhetorical (I don't know if I used the word in the correct context or even what it means but it's a long word and it makes me sound smarter).
Mount Rushmore is located in the Great Plains region of the United States.
Great Plains
The Black Hills of South Dakota are located in the Great Plains Region of the United States.
The Central Plains and the Great Plains are two major components of the larger region known as the Plains in North America. The Great Plains are a vast and flat region primarily located in the central United States, while the Central Plains are a smaller sub-region within the Great Plains. Together, they form a mostly flat landscape known for its grasslands and agricultural productivity.
Alberta
Lubbock is in the great plains region of Texas.
There are four main Great Plains regions: the Northern Great Plains, Central Great Plains, Southern Great Plains, and the Columbia Plateau. Each of these regions has its own unique characteristics and landscapes.
Low lands
Great Plains
The Black Hills are located in western South Dakota, and extend into eastern Wyoming, USA.
Most of the farm land in South Dakota is located in eastern South Dakota, or in the Great Plains region.
There are ten states in the Great Plains Region of the US.