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Tuthmosis II might never have ruled Egypt but for the early death of Wadjmose and Amenmose, the eldest sons of Tuthmosis I, leaving him as the only heir. He became the fourth ruler of Egypt's 18th Dynasty. He was apparently the oldest son of Mutnefert, a minor royal queen of Tuthmosis I, who was herself the sister of Tuthmosis I's principal queen, Ahmose. In order to strengthen his position and legitimize his rule, he was married to Hatshepsut, the oldest daughter of Tuthmosis I and Queen Ahmose.

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