Your great aunt's son is first cousin to one of your parents, and first cousin once removed to you.
That's easy cousins.
Your niece's son's son is her grandson. He is your great great nephew and you are his great great aunt or great great uncle, depending on your gender.
Your great grandmother's sister is your great great aunt and your son's great great great-aunt. He is her great great great nephew.
Your great aunt's son is first cousin to one of your parents, and first cousin once removed to you.
Your son and your mother's sister are in a "Great Nephew/Great Aunt" relationship.
You are the great aunt/uncle of your sister's son's daughter, and your sister's son's daughter is your great niece.
Your son and your mother's sister are in a "Great Nephew/Great Aunt" relationship.
Your nephew's child is your great nephew (if a boy) or great niece (if a girl). You are his or her great aunt.
Your niece's son is your grand-nephew. You are the child's grand aunt, or grand uncle (whichever applies).
Your niece's son is your great nephew. You are his great aunt or great uncle.
You granddaughter is a great great niece of your aunt. Your aunt is your granddaughter's great great aunt.
Your grand niece's son is your great grand nephew, or, some would say, your great great nephew. You are his great grand aunt or great grand uncle, or, some would say, great great aunt or great great uncle.