What role did Eliza Lucas play in the Southern Colonies?
she wrote a consititution
If your question is about drama, it would appear that Eliza Lucas had no interest in it whatsoever, and played no dramatic role. If you are talking about her role in the development of agriculture in the American South, that is another matter, as she is noted as the person who introduced the growing of indigo as a cash crop in the 18th century.
Maryland was founded by Roman Catholics who were fleeing persecution in England. The Puritans, Quakers, and other protestants who were being persecuted by England also fled to the colonies. Not all colonies were founded with religious intentions however. Southern colonies such as the Carolinas were founded for agriculture and Georgia was founded as a buffer state between the English colonies and Spanish controlled Florida.