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In 1928, Fred Griffith inoculated mice with different kinds of viruses and found that there was some kind of transforming agent within the bacterial cells that changed them.

It wasn't until later on, in 1932, when Oswald Avery figured out that this transforming agent was probably DNA.

Then later still, in 1952, Alfred Hershey and Martha Chase reenacted Griffith's experiment and confirmed that DNA was indeed the transforming agent to change cells.

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