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It depends upon which ion exchange system comes first. Anion exchange resin beads are alkaline, because they absorb anions like carbonate and sulphate and replace them with hydroxide, OH-. So it needs an alkaline pH, although not too high. Cation exchange replaces sodium, calcium, magnesium etc with hydrogen ions H+ , so its resin beads will have an acidic reaction and the water should not be alkaline, preferably neutral.

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