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Pioglitazone hydrochloride can cause fluid retention or edema (swelling), which may lead to or worsen heart failure, so tell your doctor if you have a history of these conditions. First stop taking pioglitazone hydrochloride. Then, your doctor should perform a blood glucose test, to decide what the reason is, such as caused by the drug or the Diabetes is not well controlled.

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Q: What should you do if edema occurs while taking pioglitazone hydrochloride?
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