There are no time signatures with both sharps and flats. They need to have either one, the other, or neither.
These are the keys with sharps:
1: G and e
2: D and b
3: A and f#
4: E and c#
5: B and g#
6: F# and d#
7: C# and a#
These are the ones with neither:
C and a
These are the ones with flats:
1: F and d
2: Bb and g
3: Eb and c
4: Ab and f
5: Db and bb
6: Gb and eb
7: Cb and ab
The keys represented by capital letters are major and the keys represented by lowercase letters are minor.
The key signature
There can be a total of seven flats (or sharps) in a key signature.
The key signature with six flats is the key of G-flat major.
The key signature with 7 flats is the key of C-flat major.
None. No key signature contains a mix of flats and sharps.
The scale that has two flats in its key signature is the key of Bb major.
The scale with 2 flats in its key signature is the key of Bb major.
The key with 6 flats in its key signature is the key of G flat major.
The key signature of a musical scale with two flats is Bb major.
4 sharps.
The key signature for a piece written in the key of six flats is G flat major.
There are three flats in the key signature of E flat major