Neurotransmitters are special chemicals that are produced and stored in synaptic vesicles. There are many different kinds and each vesicle can hold hundreds of them. When they are released, they cross the synaptic cleft and attach to a receptor site which may be on another nerve cell, a muscle cell, or a gland.
neurotrnsmitters
Acethylcholine
The tiny sacs in the synaptic knob are known as synaptic vessels. The synaptic vessels release chemicals into the bloodstream with each synapse.
Synaptic vesicles are found in the axon terminals of nerve cells.
Neurotransmiter, which may be Acetylcholine etc
synaptic vesicles
Neurotransmitters are stored in synaptic vesicles in the terminal bouton of pre-synaptic axons. They are released from the terminal bouton into the synaptic cleft and the neurotransmitters exert their action on the post-synaptic neurons.
a neurotransmitter
Criteria required identifying a substance as a neurotransmitter 1- ) Synthesis of the substance: • It is synthesized in the neuron • Some substances are synthesized from the Tryptophan • Rate limiting step in its synthesis • Enzymes required in the synthesis of that substance are themselves synthesized in the cell body of neuron ,then distributed throughout the neuron • Mainly found in the cell body and nerve terminal • These enzymes are stored in the presynaptic terminal of neuron, inside the synaptic vesicles. 2- ) Storage of that substance: • The neutransmitter is stored inside the synaptic vesicle of nerve terminal 3- ) Release of the neurotransmitter: • It is released from the nerve terminal usually through Ca++ dependent process following the stimulation of the nerve fiber by action potential. • Fusion of the synaptic vesicle with the nerve membrane releasing neurotransmitter outside the nerve fiber into the synaptic cleft. 4- ) Exogenous analogue (drug) of the neurotransmitter: • If drug analogue of the neurotransmitter is injected exogenously, it should mimic the same mechanism of action as done by the endogenously released neurotransmitter.
neurotransmitters
the sack like structures found inside the synaptic knob containing chemicals are called what?
Its the synaptic cleft found at the end of the axon terminal.
are endogenous chemicals which relay, amplify, and modulate signals between a neuron and another cell.[1] Neurotransmitters are packaged into synaptic vesicles that cluster beneath the membrane on the presynaptic side of a synapse, and are released into the synaptic cleft, where they bind to receptors in the membrane on the postsynaptic side of the synapse. Release of neurotransmitters usually follows arrival of an action potential at the synapse, but may follow graded electrical potentials. Low level "baseline" release also occurs without electrical stimulation.