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Both point mutations and frameshifts can result in truncated proteins. I would think that frameshifts produce stop codons more frequently, however this is based on an estimated apriori probability.

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13y ago

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What mutation causes the DNA replication to stop early?

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When a substitution of a nucleotide leads to the early addition of a STOP codon in the amino acid chain, it is called a nonsense mutation. This type of mutation results in a premature termination of protein synthesis, potentially leading to a truncated and often nonfunctional protein. Nonsense mutations can have significant effects on the organism, depending on the role of the affected protein.


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