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The simplest way would be to take the Downtown A-C-E (the blue line) from 34th Street-Penn Station to Canal Street.

You will exit the subway at the north end of the Tribeca neighborhood, just south of SoHo, at the intersection of Canal and Varick Streets. Walk one block north on Varick to Grand Street.

If you're going further east on Grand Street, then take the Uptown A or C (not the E) to 59th Street-Columbus Circle. Then transfer at 59th Street-Columbus Circle to the Downtown B or D trains (of the B-D-F-M, the orange line). Take the Downtown B or D to Grand Street (at Chrystie Street), which is in Chinatown.

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