It depends on the route you take, but if you take I-20 to US-49 to US-98 to I-10 to I-75, the halfway point is on US-98 between Hattiesburg, MS, and Mobile, AL.
Dallas
Turrell, AR
The town between Longview and Dallas on I-20 is Canton. It's in Texas.
Fredericksburg, VA
Salem, VA
Dallas if you are taking I-95 to I-20 to I-10.
About halfway between Dublin city and Tipperary town is Portlaoise.About halfway between Dublin city and Tipperary town is Portlaoise.About halfway between Dublin city and Tipperary town is Portlaoise.About halfway between Dublin city and Tipperary town is Portlaoise.About halfway between Dublin city and Tipperary town is Portlaoise.About halfway between Dublin city and Tipperary town is Portlaoise.About halfway between Dublin city and Tipperary town is Portlaoise.About halfway between Dublin city and Tipperary town is Portlaoise.About halfway between Dublin city and Tipperary town is Portlaoise.About halfway between Dublin city and Tipperary town is Portlaoise.About halfway between Dublin city and Tipperary town is Portlaoise.
I think Shasta might be pretty close.
Indianapolis is about halfway between.
The town of Marana is about halfway.
Moultrie, Ohio is halfway between Charles Town & Jackson
If you're driving, the halfway point is on I-90 in South Dakota, just east of the Missouri River. The nearest town is Kimball, SD.