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It is a 126 miles from Tampa to Fort Meyers.
125 Miles
The shortest driving distance is 127 miles taking I-75.
Fort Myers, FL is the most convenient halfway point between those two destinations. It's around 2 hours and 15 minutes to travel to Fort Meyers from Fort Lauderdale.
123 miles taking I-75 NORTH.
The halfway point between Fort Meyers, Florida and Knoxville, TN falls in or around Tifton, Georgia.
140 miles
The driving distance between Fort Lauderdale, FL and Tampa, FL is approximately 265 miles.
There are two towns named Sunrise in Florida. One is near Fort Lauderdale, 254 miles from Tampa and the other is 61 miles south of Tampa.
323 miles
Assuming you mean Fort Meyers Florida, Tampa is your closest port. What's the point of the question? Fort Lauderdale or Miami are only 20/30 miles further, but, typically, I'd expect better cruise rates out of the biggies than Tampa. Another assumption, often wrong, many people make, is the closer the better. As often as not, this is not the case. You would do better to select your destination and then find a ship.
320 miles down I-75.