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Indigestion can be caused by problems in in the digestive tract like gastroesophageal reflux disease , peptic ulcers, cancer, or abnormality of the pancreas or bile ducts. If the condition improves or disapears, the symptoms of indigestion will usually also get better.

Indigestion for which a cause cannot be found is referred to as functional dyspepsia, Functional dyspepsia is thought to happen in the area where the stomach meets the small intestine. It may be related to abnormal motility, the squeezing or relaxing action of the stomach muscle as it receives, digests, and moves food into the small intestine.

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