Thalidomide was originally used as a light sedative. It proved to be a powerful teratogen, and was withdrawn after having caused a number of very serious birth defects.
Interestingly, though, thalidomide can once again be prescribed in connection with the treatment of multiple myeloma. Safeguards are in effect to prevent the distribution of the drug to women who are pregnant, or who could become pregnant.
when was the british flag first used
Internet was first used for military purpose which used the concept of packet networking. ARPANET was the first internet protocol to be used for communication.
The 105mm HE shell was first used in 1941, used with the 105 mm Howitzer M2A1(M101) by the United States.
Smoking shelters were first used many years ago, but are more widely used today due to smoking bans etc.
The Korean war was the first time Vertical Envelopment was used, or the use of helicopters to assist troops in battle.
Kuntz and keller type
The federal government responded to the uproar over the Thalidomide crisis by passing the Kefauver-Harris Amendments of 1962.. The said industry of government, which had engineered the Thalidomide scandal in the first place, thereby only became stronger and more dangerous.
Thalidomide all went wrong because it wasn't tested properly and they skipped some vital tests before it was used on actual patients.
Dr.R.Kunz and Dr.H.Keller invented thalidomide in Germany
Thalidomide was marketed as an aid for nausea and for pregnant women to prevent morning sickness. Thalidomide was withdrawn because it was found to cause birth defects in newborns, such as missing limbs, it also caused peripheral neuropathy (nerve damage) in long time users. Thalidomide still being used as a treatment option for various forms of cancer.
It was believed to have been developed in 1944 (by Nazis) as an antidote to nerve gas (e.g., sarin). The first patient administered the drug was 10 years after in 1954.
Thalidomide.
Thalidomide was supposed to be an effective sedative for pregnant women, but thalidomide caused birth defects and peripheral neuropathy.
Dark Remedy: The Impact of Thalidomide and Its Revival as a Vital Medicine by Rock Brynner and Trent D. Stephens Suffer the Children: The Story of Thalidomide Tough Cookie: The Less Than Virtuous Tale of a Thalidomide Mum by Sheila Mottley Thalidomide and the Power of the Drug Companies (A Penguin special) by Robert Nilsson and Henning Sjostrom Dark Remedy: The Impact of Thalidomide and Its Revival as a Vital Medicineby Rock Brynner and Trent D. Stephens Suffer the Children: The Story of Thalidomide Tough Cookie: The Less Than Virtuous Tale of a Thalidomide Mum by Sheila Mottley Thalidomide and the Power of the Drug Companies (A Penguin special) by Robert Nilsson and Henning Sjostrom
Thalidomide regulates the immune response by suppressing a protein, tumor necrosis factor alpha.
Thalidomide leads to the forming of deformed and flipper like limbs in babies.
This occurred due to the fact that the first manufacturer of thalidomide was a German pharmaceutical company - which first sold this drug in October of 1957. This was followed by British approval of the drug. Subsequently, over the next ten years or so, about 2,500 "thalidomide babies" were born in Germany, and about 2,000 in Great Britain. The birth defect is called phocomelia, a shortening of the limbs, in which they appear to look like the flippers on a seal. Also, the FDA did not approve thalidomide in the U.S. (although quite a few tablets found their way to the U.S., despite the FDA ban).