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Its significance is that it was used mostly for manufacturing and trade
Lack of food and water.
Lack of Food AND water
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From Austin, you would travel north to intersect with the Santa Fe Trail, and then go west to Santa Fe. There may have been other trails that went more directly northwest.
Susan Magoffin's expedition began in May 1846 in Independence, Missouri, as part of the Santa Fe Trail.
Mexico city and Perote
The Santa Fe trail lead to Santa Fe, New Mexico.
The Santa Fe trail lead to Santa Fe, New Mexico.
Santa Fe is the capital city in New Mexico.
The address of the Santa Fe Public Library is: 145 Washington Avenue, Santa Fe, 87501 2016