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This largely depends on the amount drank. Hellium is non poisonous but can cause asphyxiation.

A very small amount would do little to a human except freeze the first layer(s) of the mouth/esophagus. Also, liquefied gasses expand greatly as the re-vaporize. There is a slight chance for a sudden pressure change to occur. (more then likely you would have to burp loudly)

For more that a little bit:

Everything from extreme frost bite to death could occur. Each of the problems listed above would be magnified. If, by chance, you could get the liquid to the stomach before it vaporized the sudden increase in pressure would rupture the stomach. This would not be you primary concern. The muscles of the esophagus would probably freeze before a large amount could actually be swallowed.

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Q: What would happen if you opened the lid that contains helium gas?
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