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When a protein has lost its 3D structure it becomes polypeptide chain with some secondary structure elements are they may simply degraded to it primary structure which is polypeptide chain.

3D structure is a native structure of protein molecule where it can have the correct folding stabilized by its intra and inter molecular interactions among its residues.

Proteins can loose its structure when they are exposed to a denaturing condition which is change in buffer environment such as pH, temperature,ion salts, metals and detergents such as SDS can unravel the proteins structure. Reducing agents such as DTT or 2-mercaptoethanol or often used with heat (95 degrees) to denature the protein completely while resolving them on the gel.

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9y ago
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14y ago

Denatured.

A denatured protein is any protein that has been altered in its structure due to any of a variety of influences (ionic strength of solution, pH, temperature etc) resulting in a loss of function, such as a loss of catalytic activity. Denatured proteins tend to precipitate in solution.

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9y ago

It has lost it's tertiary structure and can no longer function and is said to be denatured.
https://www.youtube.com/watch?v=qs3xONv548I&feature=player_embedded

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9y ago

I'm not sure what you mean by 'lost its 3D' but I think you might mean when a protein is broken down or heated it becomes denatured.

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13y ago

denaturation

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11y ago

It has become denatured

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14y ago

Denaturation

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11y ago

Degraded and non-functional.

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11y ago

denuration

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10y ago

denatured

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Q: When a protein loses its natural shape it is said to be what?
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