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It appears that he had some of 'brain incident' in 2004 or 2005, which was later thought to be a minor stroke. Since he posted in December 2007 that he had been 'newly diagnosed with the early onset of Alzheimers disease, this would probably mean about November 2007, or possibly a bit earlier.

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Q: When did Terry Pratchett find out he had Alzheimer's disease?
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