The answer is in late 1793 and before that in 1762
1793 is when yellow fever was in philadelphia.
1905 in New Orleans. See Related Link.
over four thousand people died from yellow fever in philadelphia
over 4 thousand people died from yellow fever
In 1793.
More than likely from mosquitoes
Philadelphia, Pennsylvania
yellow fever
yellow fever
Mayor Samuel Powel died of Yellow Fever in 1793, according to the National Park Service at Independence Mall. It says so on the signage of his home in Philadelphia, PA.
December 1793
It was the Yellow Fever that struck Philadelphia in 1793. It was a pandemic, meaning that it spread throughout the country.