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Brainiac is not capable of dying due to being a Kryptonian Artificial Intelligence program however he was temporary damaged by the Fortress of Solitude in the fifth season episode titled "Solitude" and he was destroyed by the Dagger that was created from the Fortress of Solitude that Jor-El gave to Clark Kent in the fifth season 22nd episode that was titled "Vessel," Jor-El while in control of Lionel Luthor's body was capable of destroying Brainiac's human form in the 21st episode of Season 5 titled "Oracle" and Clark Kent along with the assistance from the Legion of Superheroes were able to destroy Brainiac in the 8th season episode titled "Legion" however The Legion used the opportunity to take Brainiac into the future and reprogram him into Brainiac 5, a purified version of the corrupted Brainiac that he had fought before.

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9y ago
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11y ago

Clark kills him in season 7 episode 20.

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Q: When does brainiac die in Smallville?
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