Muscle contraction results
actin and myosin
actin filaments
actin (thin) filaments
During muscle contraction, myosin cross bridges attach to active sites of ACTIN FILAMENTS.
During skeletal muscle contraction myosin cross bridges attach to active sites of actin filaments. Actin filaments bind ATP. Their growth is regulated by thymosin and profilin.
The head of the myosin filament "walks along" the actin filament forming cross bridges between the two.
ATP not ADP binds to actin-myosin and is cleaved by to ADP.
Myosin functions as an ATPase utilizing ATP to produce a molecular conformational change of part of the myosin and produces movement. Movement of the filaments over each other happens when the globular heads protruding from myosin filaments attach and interact with actin filaments to form crossbridges. The myosin heads tilt and drag along the actin filament a small distance (10-12 nm). The heads then release the actin filament and adopt their original conformation.
Cross bridge
myosin binding to actin
Energisation of the head takes place, then cross bridge linkage follows
Yes, it does. During a contraction, myosin heads interact with actin filaments to form cross-bridges. The myosin head pivots, producing motion. Thick filaments contain titin strands that recoil after stretching.