Big River - musical - was created in 1985.
Big Deal - musical - was created in 1986.
The Big Three - musical group - was created in 1961.
The Big Gay Musical was created on 2009-08-09.
Blue's Big Musical Movie was created on 2000-10-06.
Big Two-Hearted River was created in 1925.
Big River - Jimmy Nail song - was created in 1995.
Big-headed Amazon River turtle was created in 1812.
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I don't know of any that early, but in the 1950' s we had ' Showboat' and tte song "Old Man River" and in the 1970's we had 'Big River' with the song 'River In The Rain'.
Our Day Out - musical - was created in 1987.
Showtune - musical - was created in 1985.
Tamagotchi... The Musical was created in 2011.