That is not known. but April 12, 1961,was the first known whit a man.
offisaly.
The first manned space flight was by the U.s.s,R in the Sputnik.
The Mercury Program was the first manned space flight program,
it was the russias space station
Manned space travel to Titan is not yet feasible, but probes have been there already.
The first US space laboratory was Skylab
On May 5 1961 Mercury 3 took Alan Shepard to space making it America's first manned space flight
in 1961
The first manned crew to spend Christmas in space was during the Apollo 8 mission. They were the first humans to see the dark side of the moon.
Apollo-Soyuz
SpaceShipOne
On April 12, 1961
Mercury.