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The Cyclops of Greek myth likely never existed, but science gives that there is such a condition that produces one eye in animals and may do so with humans.

Cyclopia (also cyclocephaly or synophthalmia) is a rare form of holoprosencephaly and is a congenital disorder (birth defect) characterized by the failure of the embryonic prosencephalon to properly divide the orbits of the eye into two cavities. Its incidence is 1 in 16,000 in born animals, and 1 in 250 in embryos.

Although cyclopia is very rare, several cyclopic human babies are preserved in medical museums (e.g. The Vrolik Museum, Amsterdam).

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